ISME雜志旨在促進微生物生態學的多樣性和綜合性領域，涵蓋微生物生命的廣度，包括細菌、古生菌、微生物真核生物和病毒。特別鼓勵具有廣泛生物學利益和影響的貢獻。《日刊》范圍內特別感興趣的主題包括下列主題:
The ISME Journal seeks to promote diverse and integrated areas of microbial ecology spanning the breadth of microbial life, including bacteria, archaea, microbial eukaryotes, and viruses. Contributions of broad biological interest and impact are especially encouraged. Topics of particular interest within the journal's scope include those listed below:
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