《減少危害》雜志發表的研究集中于精神活性藥物的普遍使用模式、旨在控制它們的公共政策，以及尋找有效的方法來減少藥物和藥物政策所帶來的醫療、公共衛生和社會后果。我們將“減少危害”定義為“旨在減少合法和非法使用精神活性藥物的健康、社會和經濟成本，但不一定減少藥物消費的政策和項目”。

Harm Reduction Journal publishes research focusing on the prevalent patterns of psychoactive drug use, the public policies meant to control them, and the search for effective methods of reducing the adverse medical, public health, and social consequences associated with both drugs and drug policies. We define 'harm reduction' as 'policies and programs which aim to reduce the health, social, and economic costs of legal and illegal psychoactive drug use without necessarily reducing drug consumption'.